Question category: Haematology
A 64 year old male presents with general malaise, weight loss and night sweats. He also complains of abdominal discomfort in the left upper quadrant. On examination there is evidence of massive splenomegaly. Bloods revealed a low haemoglobin and neutropenia. A blood film reveals leukoerythroblastosis with tear drop poikilocytosis and megakaryocyte fragments. What is the most likely diagnosis?